A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics |
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| Authors: | Amir Nasajpour Sahar Ansari Chiara Rinoldi Afsaneh Shahrokhi Rad Tara Aghaloo Su Ryon Shin Yogendra Kumar Mishra Rainer Adelung Wojciech Swieszkowski Nasim Annabi Ali Khademhosseini Alireza Moshaverinia Ali Tamayol |
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| Affiliation: | 1. Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA;2. Harvard‐MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA;3. Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA, USA;4. Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland;5. Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, USA;6. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA;7. Functional Nanomaterials Institute for Materials Science, Kiel University, Kiel, Germany;8. Department of Chemical Engineering, Northeastern University, Boston, MA, USA;9. Center of Nanotechnology, King Abdulaziz University, Jeddah, Saudi Arabia;10. Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, Republic of Korea;11. Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Lincoln, NE, USA |
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| Abstract: | Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering. |
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| Keywords: | electrospinning guided tissue regeneration osteoconductive periodontal regeneration zinc oxide |
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