High‐Efficient Clearable Nanoparticles for Multi‐Modal Imaging and Image‐Guided Cancer Therapy |
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Authors: | Qiaolin Wei Yao Chen Xibo Ma Jianfeng Ji Yue Qiao Bo Zhou Fei Ma Daishun Ling Hong Zhang Mei Tian Jie Tian Min Zhou |
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Affiliation: | 1. PET Center, Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, P. R. China;2. Institute of Translational Medicine, Zhejiang University, Hangzhou, P. R. China;3. Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, P. R. China;4. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China;5. Key Laboratory of Early Warning and Intervention of Malignant Tumor (Ministry of Education), Zhejiang University, Hangzhou, P. R. China;6. State Key Laboratory of Modern Optical Instrumentations, Zhejiang University, Hangzhou, P. R. China |
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Abstract: | Renal‐clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/organs due to their highly efficient clearance characteristics. However, their tumor uptake is relatively low due to the short blood circulation time and rapid body elimination. Here, this problem is addressed by developing renal‐clearable nanoparticles by controlled coating of sub‐6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica nanoparticles (pore size ≈6 nm) for multimodal application. High tumor uptake of the as‐synthesized nanoparticles (abbreviated as MDNs) is achieved due to the longer blood circulation time. The MDNs also show excellent performance in bimodal imaging. Moreover, the MDNs demonstrated a photothermally sensitive drug release and pronounced synergetic effects of chemo‐photothermal therapy, which were confirmed by two different tumor models in vivo. A novel key feature of the proposed synthesis is the use of renal‐clearable CuSNDs and biodegradable mesoporous silica nanoparticles which also are renal‐clearable after degradation. Therefore, the MDNs would be rapidly degraded and excreted in a reasonable period in living body and avoid long‐term toxicity. Such biodegradable and clearable single‐compartment theranostic agents applicable in highly integrated multimodal imaging and multiple therapeutic functions may have substantial potentials in clinical practice. |
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Keywords: | biodegradation multimodal imaging nanoplatforms renal clearance theranostics |
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