Actively Targeted Deep Tissue Imaging and Photothermal‐Chemo Therapy of Breast Cancer by Antibody‐Functionalized Drug‐Loaded X‐Ray‐Responsive Bismuth Sulfide@Mesoporous Silica Core–Shell Nanoparticles |
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| Authors: | Lihua Li Yao Lu Chunyan Jiang Ye Zhu Xianfeng Yang Xiaoming Hu Zefeng Lin Yu Zhang Mingying Peng Hong Xia Chuanbin Mao |
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| Affiliation: | 1. China–Germany Research Center for Photonic Materials and Device the State Key Laboratory of Luminescent Materials and Devices, and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China;2. Guangdong Key Lab of Orthopedic Technology and Implant, Department of Orthopedics Guangzhou General Hospital of Guangzhou Military Command 111 Liuhua Road, Guangzhou, Guangdong, China;3. Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, OK, USA;4. School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China |
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| Abstract: | A theranostic platform combining synergistic therapy and real‐time imaging attracts enormous attention but still faces great challenges, such as tedious modifications and lack of efficient accumulation in tumor. Here, a novel type of theranostic agent, bismuth sulfide@mesoporous silica (Bi2S3@mPS) core‐shell nanoparticles (NPs), for targeted image‐guided therapy of human epidermal growth factor receptor‐2 (HER‐2) positive breast cancer is developed. To generate such NPs, polyvinylpyrrolidone decorated rod‐like Bi2S3 NPs are chemically encapsulated with a mesoporous silica (mPS) layer and loaded with an anticancer drug, doxorubicin. The resultant NPs are then chemically conjugated with trastuzumab (Tam, a monoclonal antibody targeting HER‐2 overexpressed breast cancer cells) to form Tam‐Bi2S3@mPS NPs. By in vitro and in vivo studies, it is demonstrated that the Tam‐Bi2S3@mPS bear multiple desired features for cancer theranostics, including good biocompatibility and drug loading ability as well as precise and active tumor targeting and accumulation (with a bismuth content in tumor being ≈16 times that of nontargeted group). They can simultaneously serve both as an excellent contrast enhancement probe (due to the presence of strong X‐ray‐attenuating bismuth element) for computed tomography deep tissue tumor imaging and as a therapeutic agent to destruct tumors and prevent metastasis by synergistic photothermal‐chemo therapy. |
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| Keywords: | active tumor targeting photothermal‐chemo therapy porous silica theranostic nanoparticles X‐ray computed tomography |
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