The role of complement, antibody, and tumor necrosis factor alpha in the killing of Plasmodium falciparum by the monocytic cell line THP-1 |
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| Authors: | LM Kumaratilake A Ferrante T Jaeger SD Morris-Jones |
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| Affiliation: | Department of Immunology and University of Adelaide Department of Paediatrics, Women's and Children's Hospital, North Adelaide, South Australia. lkumarat@adelaide.medicine.edu.au |
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| Abstract: | Killing of Plasmodium falciparum blood forms by the differentiated human myelomonocytic THP-1Mo cell line was studied by a radiometric assay. Results showed that parasite killing was promoted by complement, antimalarial antibody, and the cytokines tumor necrosis factor alpha and gamma interferon. Differentiated THP-1Mo appears to be a useful monocytic cell line for the study of mechanisms of immunity to Plasmodium. |
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