Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism with susceptibility to renal cell carcinoma/prostate cancer

In this study, we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α(HIF1α) 1772C/T gene polymorphism (rs 11549465) and renal cell carcinoma (RCC)/prostate cancer risk. We searchedfor relevant studies (before March 1, 2019) on Cochrane Library, Embase, and PubMed. Studies meeting the inclusioncriteria were recruited into this meta-analysis. The outcome of dichotomous data was showed in the way of oddsratios (OR), and 95% confidence intervals (CI) were also counted. In this investigation, there was no associationbetween HIF1α 1772C/T gene polymorphism and susceptibility to RCC in Caucasians, Asians as well as overallpopulations. In addition, HIF1α 1772C/T gene polymorphism was not found to be relevant to the survival in RCC.Interestingly, the T allele was relevant to prostate cancer risk in all populations, but not in Caucasians and Asians.However, the TT genotype and the CC genotype were not related to prostate cancer susceptibility in Asian,Caucasian, and all populations. In conclusion, the T allele of the HIF1α 1772C/T gene polymorphism was related toprostate cancer risk in the overall populations.