硅橡胶表面壳聚糖载铜凝胶涂层的制备及其抗菌功能

在硅橡胶表面制备一种具有抗感染功能的涂层—壳聚糖载铜凝胶涂层。为了克服硅橡胶的生物惰性,在其表面制备涂层,先用逐步化学接枝法对其表面进行活化预处理,然后化学接枝壳聚糖载铜凝胶涂层。对比浸泡前后涂层的形貌,研究了活化预处理对功能化涂层与硅橡胶基体之间结合性能的影响。结果表明,用化学接枝法可在硅橡胶表面生成丰富的活性官能团从而提高了功能化涂层与硅橡胶的结合强度。载铜功能化涂层使硅橡胶导管具有良好的抗菌功能。

Preparation and Antibacterial Function of an Cu-bearing Chitosan Coating on Silicone Rubber Surface

In order to solve the infection caused by the indwelling catheter, an anti-infective Cu-bearing chitosan coating was prepared on the silicone rubber surface. But it is difficult to prepare a coating on the surface of silicone rubber due to its biological inertness. Therefore, chemical grafting was used to activate the silicone rubber by the dopamine pretreatment, which provides abundant functional groups on the activated silicone rubber surface. The surface morphology and surface properties of the silicone rubber after surface activation pretreatment were characterized by the active functional groups. Onto which, subsequently, the Cu-bearing chitosan coating could be chemically grafted, and then the surface morphology was compared for the coatings before and after immersion test. The effectiveness of pretreatment process was assessed by the bonding force between the functionalized coating and the silicone rubber. It follows that the abundant functional groups offered by the pretreatment on the activated silicone rubber surface may be beneficial for enhancing the adhesive strength of the functionalized coating to the silicon rubber. Thereby, the Cu-bearing chitosan coating makes the silicone rubber catheter have good antibacterial function.