| ~(18)F-DOPA制备研究进展 |
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| 引用本文： | 贾丽娜,张岚. ~(18)F-DOPA制备研究进展[J]. 同位素, 2017, 30(1): 71-77. DOI: 10.7538/tws.2017.30.01.0071 |
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| 作者姓名： | 贾丽娜 张岚 |
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| 作者单位： | 中国科学院上海应用物理研究所放射化学与工程技术部,上海201800;中国科学院钍基熔盐堆核能系统卓越创新中心,上海201800;中国科学院核辐射与核能技术重点实验室,上海201800 |
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| 基金项目： | 国家自然科学基金(11505269) |
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| 摘 要： | 6-[~(18)F]氟-L-多巴(~(18)F-DOPA)为神经系统疾病和脑部肿瘤的理想示踪剂,广泛用于神经内分泌瘤的显像。本文综述近几年亲电取代法和亲核取代法合成~(18)F-DOPA取得的新进展,重点介绍新型标记前体和手性相转移催化剂在亲核取代法制备~(18)F-DOPA中的应用。
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| 关 键 词： | 18F-DOPA 亲核取代 新型标记前体 手性相转移催化剂 |
Research Progress in the Preparation of 18F-DOPA |
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| JIA Li-na,ZHANG Lan. Research Progress in the Preparation of 18F-DOPA[J]. Isotopes, 2017, 30(1): 71-77. DOI: 10.7538/tws.2017.30.01.0071 |
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| Authors: | JIA Li-na ZHANG Lan |
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| Affiliation: | 1.Department of Radiochemistry and Engineering, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;2.CAS center for excellence TMSR energy system, Shanghai 201800, China;3. Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, CAS, Shanghai 201800, China |
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| Abstract: | [18F]6-fluoro-3,4-dihydroxy-L-phenylalanine (18 F-DOPA) has been known to be a useful radiotracer for neuropsychiatric diseases and brain malignancies,and it is also abundantly used for visualizing neuroendocrine tumors at present.However,its more widespread clinical use was hampered by the lack of a high specific activity,high yielding labeling method.This review mainly summarized new developments in the synthesis of 18 F-DOPA with electrophilic reactions and nucleophilic substitution reactions in recent years.Among these,considerable advances in nucleophilic synthesis had been achieved by developing novel precursors and utilizing chiral phase-transfer catalysts (cPTC) mediated fluorinations allowing for the production of 18F-DOPA in high specific activity and high radiochemical yield. |
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| Keywords: | 18F-DOPA nucleophilic substitution new precursor chiral phase transfer catalyst |
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