| 有机碱催化下乳酸乙酯乙酸酯的合成 |
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| 引用本文： | 肖毅,黄红梅,尹笃林,赵玉霞,王季惠. 有机碱催化下乳酸乙酯乙酸酯的合成[J]. 工业催化, 2012, 20(2): 66-69. DOI: 10.3969/j.issn.1008-1143.2012.02.016 |
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| 作者姓名： | 肖毅 黄红梅 尹笃林 赵玉霞 王季惠 |
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| 作者单位： | 1.化学生物学及中药分析教育部重点实验室，湖南 长沙 410081;2.湖南师范大学精细催化合成研究所，湖南 长沙 410081 |
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| 基金项目： | 国家自然科学基金（20572021;20805014）资助项目;湖南省自然科学基金（09JJ3018）资助项目;湖南省教育厅科学研究基金（11C0809）资助项目 |
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| 摘 要： | 在1-甲基咪唑等有机碱催化下，乳酸乙酯与乙酸酐经乙酰化反应高效合成乳酸乙酯乙酸酯。单因素优化法得到适宜的反应条件为：1-甲基咪唑为催化剂，催化剂用量为乳酸乙酯物质的量的5.00%，n(乳酸乙酯)∶n(乙酸酐)=1∶1.2，回流反应2 h，目标产物乳酸乙酯乙酸酯收率为98.5%。该方法反应时间短，产物收率高，操作简便，具有工业化应用前景。
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| 关 键 词： | 催化化学 乳酸乙酯乙酸酯 乳酸乙酯 乙酰化反应 1-甲基咪唑 |
Synthesis of ethyl acetolactate catalyzed by organic bases |
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| XIAO Yi , HUANG Hongmei , YIN Dulin , ZHAO Yuxia , WANG Jihui. Synthesis of ethyl acetolactate catalyzed by organic bases[J]. Industrial Catalysis, 2012, 20(2): 66-69. DOI: 10.3969/j.issn.1008-1143.2012.02.016 |
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| Authors: | XIAO Yi HUANG Hongmei YIN Dulin ZHAO Yuxia WANG Jihui |
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| Affiliation: | 1.Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research of Ministry of Education, Changsha 410081, Hunan, China; 2.Institute of Fine Catalysis and Synthesis, Hunan Normal University, Changsha 410081, Hunan, China |
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| Abstract: | Using organic base 1-methyl imidazole as the catalyst,ethyl acetolactate was efficiently synthesized by acetylation of ethyl lactate with acetic anhydride. The results showed that the yield of the objective product ethyl acetolactate of 98.5% was attained under the optimum reaction condition as follows ： the dosage of the catalyst 1-methyl imidazole 5.00% （ molar ratio） of ethyl lactate amount, n （ ethyl lactate ） ： n （acetic anhydride） = 1： 1.2, and reaction time 2 h. It is a promising route for industrial production of ethyl acetolactate due to its advantages such as short reaction time,high product yield and facile operation. |
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| Keywords: | catalytic chemistry ethyl acetolactate ethyl lactate acetylation 1-methyl imidazole |
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