| 氘标色氨酸和氘标川芎哚的合成研究 |
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| 引用本文： | 唐刚华,王世真,姜国辉.氘标色氨酸和氘标川芎哚的合成研究[J].核技术,1999,22(9):573-575. |
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| 作者姓名： | 唐刚华 王世真 姜国辉 |
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| 作者单位： | 中国医学科学院,中国协和医科大学北京协和医院,北京,100730 |
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| 基金项目： | 高等学校博士学科点专项科研基金，国家自然科学基金 |
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| 摘 要： | 以色氨酸和氘水及色氨酸和氯化氘两种交换反应合成氘标色氨酸，其产率分别为９５％和９２％．氘标总丰度分别为９６．２％和９８．５％。以色氨酸和氘水反应合成的氘标色氨酸为原料，经环化，氧化脱羧及水解等反应合成氘标川芎哚，产率为１１．６％，氘标总丰度约为９０５，结果表明，合成的氘标川芎哚满足药物代谢研究的需要。
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| 关 键 词： | 氘标色氨酸 氘标川芎哚 合成 |
Deuteration of tryptophan and perlolyrine |
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| TANG Ganghua,WANG Shichen,JIANG Guohui.Deuteration of tryptophan and perlolyrine[J].Nuclear Techniques,1999,22(9):573-575. |
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| Authors: | TANG Ganghua WANG Shichen JIANG Guohui |
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| Abstract: | Deuterated tryptophan was prepared by simple exchange reactions in DC1 orD2O solution. The yield and abundance of deuterated tryptophan obtained from usingDC1 as the deuterium solute was 92% and 98.5% respectively, whereas that by usingD2O was 95% and 96.2% respectively. Deuterated perlolyrine was synthesizedstarting from deuterated tryptophan via acid-catalyzed ring-closure, aromatisationand hydrolysis, with a yield of 11.6% and abundance of about 95%. The labelledperlolyrine was suitable for studying drug metabolism. |
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| Keywords: | Deuterated tryptophan Deuterated perlolyrine Synthesis |
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