Binding of pertussis toxin to lipid vesicles containing glycolipids |
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| Authors: | SZ Hausman DL Burns |
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| Affiliation: | Division of Bacterial Products, Food and Drug Administration, Bethesda, Maryland 20892. |
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| Abstract: | ![]()
The binding of pertussis toxin and its B oligomer to lipid vesicles containing glycosphingolipids was studied. Both pertussis toxin and the B oligomer bound to lipid vesicles containing ganglioside GD1a. Binding of pertussis toxin to these vesicles decreased upon treatment of the vesicles with neuraminidase, suggesting that sialic acid residues are important for efficient binding of the toxin to GD1a. |
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