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Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction |
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| Authors: | Timothy R Nurkiewicz Dale W Porter Ann F Hubbs Jared L Cumpston Bean T Chen David G Frazer and Vincent Castranova |
| Affiliation: | (1) Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA;(2) Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, USA;(3) Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA |
| Abstract: | BackgroundWe have shown that pulmonary exposure to fine particulate matter (PM) impairs endothelium dependent dilation in systemic arterioles. Ultrafine PM has been suggested to be inherently more toxic by virtue of its increased surface area. The purpose of this study was to determine if ultrafine PM (or nanoparticle) inhalation produces greater microvascular dysfunction than fine PM. Rats were exposed to fine or ultrafine TiO2 aerosols (primary particle diameters of ~1 μm and ~21 nm, respectively) at concentrations which do not alter bronchoalveolar lavage markers of pulmonary inflammation or lung damage. |
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