新型肿瘤热疗用温敏凝胶的制备与表征

采用化学共沉淀结合水热处理的方法,控制一定的反应条件,制备了碳纳米管/四氧化三铁(CNTs/Fe3O4)热种子材料,然后以壳聚糖温敏凝胶为载体,将CNTs/Fe3O4复合材料分散到凝胶中,制备出微波靶向热疗用碳纳米管-四氧化三铁-壳聚糖温敏凝胶。碳纳米管复合热种子材料在凝胶体系中分布均匀,与载体不发生化学反应,25 W下辐照10 min,当CNTs/Fe3O4复合材料的质量浓度为20 mg/mL时,体系温度在初始温度基础上升高了38.7℃,在微波场中具有良好的产热能力,可以满足微波热疗的要求。

Preparation and characterization of a novel thermosensitive gels for tumor hyperthermia

A CNTs/Fe_3O_4 thermo-seed material is prepared by a simple and effective coprecipitation and hydrothermal treatment,then carbon nanotubes composite-chitosan thermosensitive gels are prepared and characterized.In this system chitosan thermosensitive gels are used as the carrier with CNTs/Fe_3O_4 dispersed in it.CNTs composite are dispersed homogeneously in the carrier,and there are no chemical reactions between CNTs composite and gels components.Nano thermal-seed materials has a good heat production capacity in the microwave field,and are distributed uniformly in the gel system.Under these conditions such as microwave radiation of 25 W for 10 minutes and 20 mg/mL of CNTs/Fe_3O_4,the temperature of the system can be increased by 38.7℃.The result indicates that the thermosensitive gels have significant potential for application in electromagnetic wave absorption in tumor hyperthermia.