Plateletapheresis with a next generation blood cell separator |
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Authors: | EA Burgstaler AA Pineda BM Potter R Brown |
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Affiliation: | Department of Biological Sciences, University of Exeter, Devon, UK. A.J.Willetts@exeter.ac.uk |
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Abstract: | Baeyer-Villiger monooxygenases (BVMOs) are enzymes able to perform highly regio-plus steroselective nucleophilic and electrophilic biooxygenations on various substrates. The resultant chiral products (lactones and sulfoxides) can be valuable for the chemoenzymatic synthesis of a wide range of useful compounds. Recent studies have provided a number of alternative active-site models that attempt to explain the exquisite and unusual selectivity of BVMOs. This article reviews some of the established applications, and considers the merits of the various predictive models. |
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