Synthesis of pH-sensitive hollow polymer microspheres and their application as drug carriers |
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| Authors: | Xiaoying Yang Liting Chen Feng Bai |
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| Affiliation: | a School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China
b Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | The pH-sensitive hollow poly(N,N′-methylene bisacrylamide-co-methacrylic acid) (P(MBAAm-co-MAA)) microspheres were prepared by a two-stage distillation precipitation polymerization to afford a core-shell poly(methacrylic acid)/poly(N,N′-methylene bisacrylamide-co-methacrylic acid) (PMAA/(P(MBAAm-co-MAA))) microsphere with subsequent removal of poly(methacrylic acid) (PMAA) core. PMAA/P(MBAAm-co-MAA) core-shell microspheres were synthesized by the second-stage copolymerization of N,N′-methylene bisacrylamide (MBAAm) as crosslinker and the functional methacrylic acid (MAA) comonomer in acetonitrile with 2,2′-azobisisobutyronitrile (AIBN) as initiator. The pH-responsive properties of hollow P(MBAAm-co-MAA) microspheres were investigated by dynamic laser scattering (DLS). The loading and controlled-release behavior of the drug for hollow P(MBAAm-co-MAA) microspheres was strongly dependent on the pH values with doxorubicin hydrochloride (DXR) as a model molecule. The core-shell and hollow polymer microspheres were characterized by transmission electron microscopy (TEM), Fourier-transform infrared spectra (FT-IR), DLS and elemental analysis. |
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| Keywords: | pH-sensitive hollow polymer microspheres Distillation precipitation polymerization Controlled-drug release |
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