用高血脂小鼠模型评价降血脂保健食品可行性的探讨

目的:建立高血脂小鼠模型并对模型的稳定性和在降血脂保健食品功能检测研究中的实用性进行初步评价。方法:采用高脂饲料喂养法,观察小鼠进食高脂饲料60d内血脂变化情况,从而评价高血脂小鼠模型在60d内的稳定性。将大鼠与小鼠在同一时间,相同的实验条件下,进行降血脂功能检测实验,观察两种保健食品对高血脂小鼠和高血脂大鼠血脂各项指标的影响。结果:给小鼠饲喂高脂饲料30d可以造成高血脂模型,在继续饲喂高脂饲料30d里,观察到此高血脂模型能够继续维持。两种不同的保健食品影响高血脂小鼠血脂三项指标的情况与对高血脂大鼠的影响结果相一致。结论:在降血脂保健食品功能评价实验中用小鼠代替大鼠基本可行。

The Possibility of Using Hyperlipemia Mice as Model for Evaluating the Function of Declining Blood Lipids Food

Objective: Establish a hyperlipemia mice model instead of rat model and investigate the possibility for detecting blood lipids functional food. MethodMice feed on high lipids food. Investigate the statistic changes of blood lipids in 60 days. At the same time and condition,using rats and mice models for detecting the function of declining blood lipids food. Two kinds of health functioning foods are observed by detecting the level changes of different blood lipids on different kinds of models. ResultMice feed on high lipids food for 30 days can be used as hyperlipemia model. In 30 days continuing feeding,the high blood lipids level stays steadily. The level changes of three kinds of lipids selected for indicators between mice and rats models make no differences. Conclusion: It is possible,using mice instead of rats as a model for evaluating the function of declining high blood lipids food.