| 自制美沙西汀-甲氧基-~(13)C的表征 |
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| 引用本文： | 卢伟京,卢浩,杨维成,管樑,朱承谟,刘卫霞,李帅,徐仲杰,陈素芸,姜磊.自制美沙西汀-甲氧基-~(13)C的表征[J].同位素,2010,23(4):216-220. |
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| 作者姓名： | 卢伟京 卢浩 杨维成 管樑 朱承谟 刘卫霞 李帅 徐仲杰 陈素芸 姜磊 |
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| 作者单位： | [1]上海化工研究院,上海200062 [2]上海交通大学医学院附属瑞金医院核医学科,上海200025 |
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| 基金项目： | 国家高技术研究发展计划项目 |
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| 摘 要： | 采用新的方法,以甲醇-13C为原料直接合成了美沙西汀-甲氧基-13C,并对其进行了HPLC、LC-MS和1HMNR等分析。结果表明,所合成的样品是目标产品,产率为70.0%,13C丰度为99%,纯度为99.8%。与经典的合成方法比较,本方法具有较好的经济效益。使用本方法自制的美沙西汀-甲氧基-13C进行小鼠13C-呼吸试验,结果表明,美沙西汀-甲氧基-13C可以在小鼠活体状态下正确评估其损伤和恢复情况。
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| 关 键 词： | 美沙西汀-甲氧基-13C 13C-呼吸实验 表征 |
Characterization of Methacetin-methoxy-13C |
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| LU Wei-jing,LU Hao,YANG Wei-cheng,GUAN Liang,ZHU Cheng-mo,LIU Wei-xia,LI Shuai,XU Zhong-jie,CHEN Su-yun,JIANG Lei.Characterization of Methacetin-methoxy-13C[J].Isotopes,2010,23(4):216-220. |
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| Authors: | LU Wei-jing LU Hao YANG Wei-cheng GUAN Liang ZHU Cheng-mo LIU Wei-xia LI Shuai XU Zhong-jie CHEN Su-yun JIANG Lei |
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| Affiliation: | 1. Shanghai Research Institute of Chemical Industry, Shanghai 200062, China；2. Department of Nuclear Medicine, Ruijing Hospital, Shanghai Jiao Tong University, Shanghai 200025, China |
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| Abstract: | Methacetin-methoxy-^13C was synthesized by using methanol-^13C with a novel method,and the characterization of it was performed using HPLC,LC-MS and ^1HMNR.The results indicated that the synthetic was right.And the yield of methacetin-methoxy-^13C was 70.0% with 99% ^13C abundance and 99.8% purity.Compared with the classical method,there was more benefit.The methacetin ^13C-breath test was performed with the synthetic on the live mice,which showed a precise reflection of alteration of liver function in liver injury and functional recovery. |
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| Keywords: | methacetin-methoxy-^13C ^13C-breath test characterization |
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