Different strategies for selective monoacylation of hexoaldoses in acetone |
| |
Authors: | Jose A Arcos Manuel Bernabé Cristina Otero |
| |
Affiliation: | (1) Departamento de Biocatálisis, Instituto de Catálisis, CSIC, Cantoblanco (28049), Madrid, Spain;(2) Instituto de Química Orgánica, CSIC, Madrid, Spain |
| |
Abstract: | Experimental protocols for the selective production of 6-O-acylhexoaldose emulsifiers from precursor sugars (mannose, glucose, and galactose) and corresponding fatty acids are compared.
The protocols employ an immobilized Candida antarctica lipase in a solvent (acetone) which is both easily eliminated and accepted by the European Economic Community for use as
an extraction solvent in the manufacture of foods and/or food additives. This comparative study provides guidelines for selection
of appropriate conditions for quantitative monoacylation of aldoses in acetone, on the basis of the solubilities of the precursor
sugar and the monoester in acetone at different temperatures. Although relatively low temperatures (<40°C) favor precipitation
of glucose monoesters, higher temperatures (e.g., 55°C) should be used to increase solubility of mannose and thus selectivity
of the reaction leading to the mannose ester. Galactose is transformed with poor selectivity to the desired monoester by these
procedures. Factors affecting the viability of these synthetic reactions in acetone are also discussed. |
| |
Keywords: | Aldose Candida antarctica lipase emulsifiers enzymatic synthesis food additives glucose lipases nonconventional media sugar |
本文献已被 SpringerLink 等数据库收录! |
|