| 4-羟基-3,5-二溴苯胺及脂溶性芳胺的制备方法 |
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| 引用本文： | 戴宽,张芳,朱建,梁文德,欧高雨,彭晓春,肖竹平. 4-羟基-3,5-二溴苯胺及脂溶性芳胺的制备方法[J]. 广州化工, 2010, 38(12): 91-93 |
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| 作者姓名： | 戴宽 张芳 朱建 梁文德 欧高雨 彭晓春 肖竹平 |
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| 作者单位： | 吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000;吉首大学化学化工学院,湖南,吉首,416000 |
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| 基金项目： | 湖南省自然科学基金,吉首大学大学生创新性实验计划,吉首大学引进人员科研资助项目 |
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| 摘 要： | 在NH4Cl-H2O-CH3COCH3体系中,以铁为还原剂,4-羟基-3,5-二溴硝基苯转化成4-羟基-3,5-二溴苯胺的产率达97.2%;采用正交试验,探索了反应的最佳条件:反应物与NH4Cl的摩尔比为1:2,H2O-CH3COCH3的体积比为1:1,反应时间为6h。实验证明该方法也可用于其他硝基化合物的还原,并且不会导致C-Br的还原,该方法尤其适合于硝基化合物及其对应的胺都不溶于水的情况。
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| 关 键 词： | 铁粉 NH4Cl-H2O-CH3COCH3 硝基化合物 4-羟基-3 5-二溴苯胺 |
A Method of Preparation of Aniline with Insolubility in Water and 3,5-Dibromo-4-hydroxyaniline |
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| DAI Kuan,ZHANG Fang,ZHU Jian,LIANG Wen-de,OU Gao-yu,PENG Xiao-chun,XIAO Zhu-ping. A Method of Preparation of Aniline with Insolubility in Water and 3,5-Dibromo-4-hydroxyaniline[J]. GuangZhou Chemical Industry and Technology, 2010, 38(12): 91-93 |
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| Authors: | DAI Kuan ZHANG Fang ZHU Jian LIANG Wen-de OU Gao-yu PENG Xiao-chun XIAO Zhu-ping |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Jishou University,Hunan Jishou 416000,China) |
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| Abstract: | In NH4Cl-H2O-CH3COCH3-Fe system,3,5-dibromo-4-hydroxynitrobenzene could convert to 3,5-dibromo-4-hydroxyaniline nearly in quantity（yield of 97.2%）.The optimum reaction conditions were given by orthogonal test as follows： the ratio of nnitro compound to nNH4Cl was 1：2,the ratio of Vwater to Vacetone was 1：1,and the reaction time was 6h.Several other nitro compounds were worked up in NH4Cl-H2O-CH3COCH3-Fe system and gave the target amines in high yield,which indicated that the reduction system had wide structural tolerance for nitro compound and did not lead to the reduction of C-Br.This method was especially used for the reduction of the nitro compounds（including its product） with poor solubility in water. |
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| Keywords: | iron NH4Cl-H2O-CH3COCH3 nitro compound 3 5-dibromo-4-hydroxyaniline |
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