| 岩藻聚糖硫酸酯的硫酸化修饰对其生物活性的影响 |
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| 引用本文： | 刘 岩,贾哲宇,郑 扬,王慧蕊,任丹丹,何云海,汪秋宽.岩藻聚糖硫酸酯的硫酸化修饰对其生物活性的影响[J].食品安全质量检测技术,2022,13(9):2818-2824. |
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| 作者姓名： | 刘 岩 贾哲宇 郑 扬 王慧蕊 任丹丹 何云海 汪秋宽 |
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| 作者单位： | 大连海洋大学,大连海洋大学,大连海洋大学,大连海洋大学,大连海洋大学,大连海洋大学,大连海洋大学 |
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| 基金项目： | 辽宁省教育厅科学研究项目(JL201909)、财政部和农业农村部: 国家现代农业产业技术体系资助项目(CARS-50) |
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| 摘 要： | 岩藻聚糖硫酸酯是一种硫酸化多糖,多来自于褐藻和棘皮动物,因具有多种生物活性而得到广泛研究。有研究表明岩藻聚糖硫酸酯的生物活性与其硫酸基团有关,因此对岩藻聚糖硫酸酯进行硫酸化修饰将有利于提高其生物活性。本文简述了硫酸基团对岩藻聚糖硫酸酯生物活性的影响;介绍了岩藻聚糖硫酸酯的硫酸化方法,其中包括三氧化硫-吡啶法、氯磺酸-吡啶法、三氧化硫-N,N-二甲基甲酰胺法以及浓硫酸法;最后阐述了硫酸化修饰后的岩藻聚糖硫酸酯抗凝血、抗肿瘤、抗氧化以及抗病毒等生物活性的变化,以期为岩藻聚糖硫酸酯硫酸化修饰的应用与发展提供理论参考。
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| 关 键 词： | 岩藻聚糖硫酸酯 硫酸基团 硫酸化修饰 抗凝活性 抗肿瘤活性 抗氧化活性 |
| 收稿时间： | 2022/1/14 0:00:00 |
| 修稿时间： | 2022/4/23 0:00:00 |
Effects of sulfated modification of fucoidan on its biological activity |
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| LIU Yan,JIA Zhe-Yu,ZHENG Yang,WANG Hui-Rui,REN Dan-Dan,HE Yun-Hai,WANG Qiu-Kuan.Effects of sulfated modification of fucoidan on its biological activity[J].Food Safety and Quality Detection Technology,2022,13(9):2818-2824. |
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| Authors: | LIU Yan JIA Zhe-Yu ZHENG Yang WANG Hui-Rui REN Dan-Dan HE Yun-Hai WANG Qiu-Kuan |
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| Affiliation: | College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University,College of Food Science and Engineering,Dalian Ocean University |
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| Abstract: | Fucoidan, a kind of sulfated polysaccharide, is mostly from brown algae and echinoderms, which has been widely studied because of its various biological activities. Studies have shown that the biological activity of fucoidan is positively correlated with the content and position of sulfate groups. Therefore, over sulfated fucoidan will improve its biological activity. This paper briefly described the effects of sulfate group on biological activity of fucoidan and introduced the sulfidation methods of fucoidan sulfate, including sulfur trioxide-pyridine method, chlorsulfonic acid-pyridine method, sulfur trioxide-N,N-dimethyl formamide method and concentrated sulfuric acid method. Finally, the changes of bioactivities such as anticoagulant activity, antitumor activity, antioxidant activity and antiviral activity of fucoidan modified by acidification were described, in order to provide theoretical reference for the application and development of fucoidan modified by acidification. |
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| Keywords: | fucoidan sulfate groups sulfated modification anticoagulant activity antitumor activity antioxidant activity |
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