Interconversion Studies of Betamethasone Acetate Polymorphs |
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| Authors: | Xue Ke QiNeng Ping Hua Shi |
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| Affiliation: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing, P.R. of China |
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| Abstract: | ABSTRACTThe polymorph interconversions of Betamethasone Acetate (BA) were studied under various pharmaceutical conditions, such as grinding, heating and suspending in water, based on differential scanning calorimetry, thermogravimetric analysis, and X-ray powder diffraction. There existed enantiotropic relationships between the three polymorphs of BA, which were named form II, Iα, and Iβ work, respectively. It was concluded that form II was the most stable form when suspended in water. |
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| Keywords: | KEYWORDS Polymorphs Betamethasone acetate Transformation Solubility Enantiotropy |
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