Physical-Chemical Characterization and Polymorphism Determination of Two Nimodipine Samples Deriving from Distinct Laboratories |
| |
| Authors: | Teófilo Mazon Cardoso Patrik Oening Rodrigues Hellen Karine Stulzer Marcos Antonio Segatto Silva Jivaldo do Rosário Matos |
| |
| Affiliation: | 1. Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil;2. Departamento de Química Fundamental, Instituto de Química, Universidade de S?o Paulo, S?o Paulo, SP, Brazil |
| |
| Abstract: | Knowing the characteristics of raw materials in pharmaceutical practice is both important and useful. Firstly, evaluating the physical-chemical properties of the substances that will be used must be the primary step for quality control in the pharmacy industry. This work aims at analyzing the physical-chemical characteristics of two nimodipine samples I and II derived from distinct laboratories through thermal analysis (DSC and TG/DTG), HPLC, crystallography, and microscopy. Thermal analysis showed that sample II was more unstable than I. Morphological differences concerning shape, size, and crystallinity of particles were visualized by scanning electron microscopy (SEM) and X-ray powder diffraction. To sum up, the techniques used in this study can be said to have been efficient in the characterization and evaluation of quality control of the raw material. |
| |
| Keywords: | Nimodipine Quality control Thermal and morphological analysis Polymorphism Non-isothermal kinetic analysis |
|
|
