Preparation and Evaluation of Inclusion Complexes of Commercial Sunscreens in Cyclodextrins and Montmorillonites: Performance and Substantivity Studies |
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| Authors: | Genoveva Luciana Negve Coelho Camila Braga Dornelas Kelen Carine Costa Soares Elisabete Pereira dos Santos André L Vergnanini Tereza Cristina dos Santos |
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| Affiliation: | 1. Departamento de Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil;2. Faculdade de Farmácia, Universidade Estadual de Campinas, Campinas, SP, Brazil;3. Instituto Nacional de Controle de Qualidade em Saúde, Funda??o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil |
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| Abstract: | Herein we describe inclusion complexes of commercial sunscreens in cyclodextrins and montmorillonites to generate new sunscreen derivatives with optimized functional properties such as water resistance and skin adherence. Four cyclodextrins (α-, β-, and γ-cyclodextrin, and β-dimethyl cyclodextrin) and two montmorillonites (sodium and alkylammonium) were investigated for encapsulating some commercial sunscreens. Our results reveal a good yield and inclusion products with functional properties obtained by using kneading technique on Eusolex® 2292 and Eusolex® 6007 in β-cyclodextrin and solubilization method on Eusolex® 6007 and NeoHeliopan® MA in montmorillonite. In addition, molecular modeling studies indicated flexibility as important for the intercalation of the host molecule. |
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| Keywords: | coprecipitation solubilization kneading techniques cyclodextrin montmorillonites |
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