High-Throughput Evaluation of Non-Swellable Controlled Release Matrix Tablets |
| |
Authors: | R. Panchagnula A. Gupta S. Kandavilli M. V. S. Varma |
| |
Affiliation: | Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Sector 67, S.A.S. Nagar, Punjab, India |
| |
Abstract: | AbstractDrug release from controlled-release (CR) matrix tablets involves the permeation and diffusion of water through the system. In this study, a new methodology is proposed for the measurement of water permeation and simultaneous drug release from the inert, non-swellable CR matrix tablet of diltiazem (DLT) and a correlation is made between these two processes. Cylindrical matrices were readily prepared by direct compression of pellets obtained by extrusion-spheronization. Water transport was studied using tritiated water (HTO) as a permeant in a Franz-diffusion cell and simultaneously drug release was measured. Further, dissolution was performed on USP XXI/XXII dissolution apparatus I using demineralized water. Matrices showed a steady water-uptake up to 6 h and the steady state for HTO permeation lasting from 6-h to 24-h Flux of water permeated and flux of drug released correlated well. Thus, HTO permeation through the matrix tablet and the proposed methodology can be used as a tool and/or surrogate marker for evaluation of controlled release matrix tablets. This methodology can be coined as “high-throughput” in terms of amount of labor and resources required in comparison to that of dissolution. |
| |
Keywords: | Controlled release Dissolution High throughput Permeation Diltiazem |
|
|