Formulation and Characterization of Formaldehyde Cross-linked Degradable Starch Microspheres Containing Terbutaline Sulfate |
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| Authors: | Handan Selek Selma Sahin H Suheyla Kas A Atilla Hincal Gilles Ponchel Meral T Ercan |
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| Affiliation: | 1. Hacettepe University, Faculty of Pharmacy, Ankara, Turkey;2. Université de Paris-Sud, Faculté de Pharmacie, Laboratoire de Pharmacotechnie et Biopharmacie, Chatenay-Malabry, France;3. Hacettepe University, Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey |
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| Abstract: | ABSTRACTPreparation of starch microspheres using epichlorohydrin is a time consuming method and requires around 18 hr for cross-linking reaction. To reduce reaction time, terbutaline sulfate (TBS) loaded degradable starch microspheres (DSM) were prepared using formaldehyde as the cross-linking agent. All microspheres were spherical in shape and had a porous, rough surface with a mean particle size of 18–24 μm. Whatever the cross-linking time, it was seen that the release of the TBS was not complete during the release experiments. The influence of enzyme on the degradation of microspheres was moderate. Following intravenous administration, initial uptake of microspheres by the lung was higher than those of other organs. |
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| Keywords: | Terbutaline sulfate Formaldehyde Degradable starch microspheres Degradation Biodistribution |
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