Glycerolipids as Selective Thrombin Inhibitors from the Fungus Stereum Hirsutum |
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| Authors: | Bojan Doljak Francesca Cateni Marko Anderluh Giuseppe Procida Jelena Zilic Marina Zacchigna |
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| Affiliation: | 1. Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia;2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Trieste, Trieste, Italy;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia;4. DEMREP, University of Trieste, Trieste, Italy |
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| Abstract: | ABSTRACTA dry extract of Stereum hirsutum exhibited a significant inhibitory activity on thrombin (34%). A bioassay oriented fractionation of the extract of Stereum hirsutum has led to the isolation of two active fractions. On the basis of spectroscopic data, chemical reactions, and GC-MS analysis, complex mixtures of diacylglycerophospholipids (DAGPs) and diacylglycerols (DGs) have been isolated and identified. Docking studies suggest that some isolated compounds could bind to the thrombin active site in a similar manner as previously reported phosphonate thrombin inhibitors. |
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| Keywords: | Thrombin Inhibition Mushrooms Extract Screening Docking |
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