Development and in vitro evaluation of floating rosiglitazone maleate microspheres |
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Authors: | M.R.P. Rao S.G. Borate K.C. Thanki A.A. Ranpise G.N. Parikh |
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Affiliation: | 1. AISSMS College of Pharmacy, Kennedy Road, Pune, Indiamonicarp_6@hotmail.com;3. AISSMS College of Pharmacy, Kennedy Road, Pune, India |
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Abstract: | Background: Various approaches have been used to retain the dosage form in stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extensible, or swellable systems; and superporous hydrogel systems. Aim?: The objective of this study was to prepare and evaluate floating microspheres of rosiglitazone maleate for the prolongation of gastric residence time. Method: The microspheres were prepared by solvent diffusion–evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A full factorial design was applied to optimize the formulation. Results: Preliminary studies revealed that the polymer:drug ratio, concentration of polymer, and stirring speed significantly affected the characteristics of microspheres. The optimum batch exhibited a prolonged drug release, remained buoyant for >12 hours, high entrapment efficiency, and particle size in the order of 350 μm. Conclusion: The results of 32 full factorial design revealed that the concentration of ethylcellulose 7 cps (X1) and stirring speed (X2) significantly affected drug entrapment efficiency, percentage release after 8 h and particle size of microspheres. |
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Keywords: | Ethyl cellulose factorial design floating microspheres rosiglitazone maleate solvent diffusion–evaporation |
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