Preparation and Antimicrobial Activityof Gelatin Microparticles Containing Propolis Against Oral Pathogens |
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| Authors: | M L Bruschi E H G Lara C H G Martins A H C Vinholis L A Casemiro H Panzeri |
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| Affiliation: | 1. Programa de Pós-Gradua??o em Ciências Farmacêuticas, FCFRP– USP, Av. Zeferino Vaz, s/n, Ribeir?o Preto, SP, CEP 1404-0903, Brazil;2. Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Av. Dr. Armando Salles Oliveira, 201, Franca, SP, CEP 14404-600, Brazil;3. Faculdade de Odontologia de Ribeir?o Preto, Av. Zeferino Vaz, s/n, Ribeir?o Preto, SP, CEP 14040-903, Brazil |
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| Abstract: | ABSTRACTGelatin microparticles containing propolis ethanolic extractive solution were prepared by spray-drying technique. Particles with regular morphology, mean diameter ranging of 2.27 μm to 2.48 μm, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of microparticles was evaluated against microorganisms of oral importance (Enterococcus faecalis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus mitis, Streptococcus mutans, Streptococcus sobrinus, Candida albicans, and Lactobacillus casei). The utilized techniques were diffusion in agar and determination of minimum inhibitory concentration. The choice of the method to evaluate the antimicrobial activity of microparticles showed be very important. The microparticles displayed activity against all tested strains of similar way to the propolis, showing greater activity against the strains of E. salivarius, S. sanguinis, S. mitis, and C. albicans. |
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| Keywords: | Propolis Gelatin microparticles containing propolis Antimicrobial activity Oral pathogens |
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