| 匹伐他汀钙的合成 |
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| 引用本文： | 张胜涛,李巧. 匹伐他汀钙的合成[J]. 江苏化工, 2008, 36(5): 28-30 |
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| 作者姓名： | 张胜涛 李巧 |
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| 作者单位： | 重庆大学化学化工学院,重庆,400044 |
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| 摘 要： | 以3-(2'-环丙基-4'(4'-氟苯基)-喹啉3'-基)-丙烯醛为起始原料,经缩合、还原、水解、化学拆分等4步反应制得匹伐他汀钙.该方法反应条件温和,操作简便,适合工业化生产.
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| 关 键 词： | 匹伐他汀钙 化学拆分 合成 |
Synthesis of Pitavastatin Calcium |
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| ZHANG Sheng-tao,LI Qiao. Synthesis of Pitavastatin Calcium[J]. Jiangsu Chemical Industry, 2008, 36(5): 28-30 |
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| Authors: | ZHANG Sheng-tao LI Qiao |
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| Abstract: | Pitavastatin calcium was synthesized from(E)-3-[2-cyclopropyl-4-(4-fluoro-quino-lin-3-yl)-propenal by the four steps reactions including condensation,reduction,hydrolysis and chemical resolution. This method has many advantages such as mild reaction conditions and simple procedure,which can be suitable for industry. |
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| Keywords: | pitavastatin calcium chemical separation synthesis |
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