Preparation,water solubility and rheological property of the N-alkylated mono or disaccharide chitosan derivatives |
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| Affiliation: | 1. “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania;2. “Alexandru Ioan Cuza” University, Department of Organic Chemistry, Iasi, Romania;3. “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania;1. 73100 Lda., Edifício Arcis, Rua Ivone Silva, 6, 4° piso, Lisboa, Portugal;2. UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Universidade NOVA de Lisboa, Campus da Caparica, Caparica, Portugal;1. Key Laboratory for Green Chemical Process of Ministry of Education, Key Laboratory of Novel Reactor and Green Chemical Technology of Hubei Province, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, China;2. School of Textile and Clothing, Nantong University, Nantong 226019, China;3. Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074, China;4. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China;5. Xingfa School of Mining Engineering, Wuhan Institute of Technology, Wuhan 430074, China;1. Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, 215-4, Gongneung, Nowon, Seoul 139-240, Republic of Korea;2. Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, 215-4, Gongneung, Nowon, Seoul 139-240, Republic of Korea;3. Department of Food and Microbial Technology, Seoul Women''s University, Seoul 139-774, Republic of Korea |
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| Abstract: | N-alkylation of chitosan was performed in a mixture of methanol and 1% acetic acid containing different amounts of monosaccharides or disaccharides including glucose, galactose, glucosamine, fructose, lactose, maltose and cellobiose. All the N-alkylated chitosan derivatives with monosaccharides were insoluble in aqueous solution (pH 7), while N-alkylated chitosan derivatives with disaccharides were easily soluble in distilled water, and the N-alkylated chitosan derivatives with lactose were soluble only at high pH. The degree of substitution (DS) of the N-alkylated chitosan derivatives increased with increasing disaccharides levels and with increasing reaction time. The reduced viscosity of the N-alkylated chitosan derivatives with disaccharides decreased with increasing DS. Apparent viscosity and pseudoplasticity of the N-alkylated disaccharide containing derivative solutions generally decreased with increasing DS. Although apparent viscosities of N-alkylated chitosan derivatives with low DS decreased with increase in pH or ionic strength, changes in high DS N-alkylated chitosan derivatives with pH values or ionic strength were not marked. |
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