Salimyxins and Enhygrolides: Antibiotic,Sponge‐Related Metabolites from the Obligate Marine Myxobacterium Enhygromyxa salina |
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Authors: | Stephan Felder Dr Stefan Kehraus Edith Neu Prof Dr Gabriele Bierbaum Dr Till F Schäberle Prof Dr Gabriele M König |
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Affiliation: | 1. Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn (Germany);2. Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund‐Freud‐Stra?e 25, 53105 Bonn (Germany) |
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Abstract: | Unlike their terrestrial counterparts, marine myxobacteria are hardly investigated for their secondary metabolites. This study describes three new compounds ( 1 – 3 ), named salimyxins and enhygrolides, obtained from the obligate marine myxobacterium Enhygromyxa salina. These are the first natural products obtained from Enhygromyxa species. Their structures were elucidated by spectroscopic analysis, including NMR and CD spectroscopy. Enhygrolides are closely related to the nostoclides, which were initially isolated from a cyanobacterium of the genus Nostoc. The salimyxins, representing structurally most unusual degraded sterols, are close to identical to demethylincisterol from the sponge Homaxinella sp. Salimyxin B and enhygrolide A inhibit the growth of the Gram‐positive bacterium Arthrobacter cristallopoietes (MIC salimyxin B, 8 μg mL?1; enhygrolide A, 4 μg mL?1). |
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Keywords: | Enhygromyxa salina marine myxobacteria natural products structure elucidation |
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