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Discovery of NVP‐LEQ506, a Second‐Generation Inhibitor of Smoothened |
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| Authors: | Dr Stefan Peukert Dr Feng He Miao Dai Rui Zhang Yingchuan Sun Dr Karen Miller‐Moslin Michael McEwan Dr Bharat Lagu Kate Wang Dr Naeem Yusuff Aaron Bourret Arun Ramamurthy Dr Wieslawa Maniara Adam Amaral Anthony Vattay Anlai Wang Ribo Guo Jing Yuan John Green Dr Juliet Williams Dr Silvia Buonamici Dr Joseph F Kelleher III Dr Marion Dorsch |
| Affiliation: | Novartis Institutes for Biomedical Research (NIBR), 250 Massachusetts Avenue, Cambridge, MA 02139 (USA) |
| Abstract: | |
| Keywords: | antitumor agents hedgehog signaling medicinal chemistry pyridazines smoothened inhibitors |