| 99Tcm-MAG2-Ade肿瘤显像剂的合成及其生物活性研究 |
| |
| 引用本文： | 赵云岭,张春丽,齐传民,游桂荣,付占立,郭凤琴,王荣福.99Tcm-MAG2-Ade肿瘤显像剂的合成及其生物活性研究[J].核化学与放射化学,2005,27(2):82-86. |
| |
| 作者姓名： | 赵云岭 张春丽 齐传民 游桂荣 付占立 郭凤琴 王荣福 |
| |
| 作者单位： | 北京师范大学,化学系,北京,100875;北京大学,第一医院,核医学科,北京,100034 |
| |
| 基金项目： | 国家自然科学基金资助项目(20171008和20371009);北京师范大学青年科学基金(理科)资助项目(107179) |
| |
| 摘 要： | 为了制备肿瘤显像剂^99Tc^m标记肽，合成并表征了新的碱基修饰的小肽配体9-N-(S-三苯甲基巯基乙酰)二甘氨酰氨基乙基]腺嘌呤(Tr—MAG2-Ade)。通过直接标记法得到了水溶性配合物^99Tc^m-MAGz—Ade，并对其体外稳定性进行了检测。在荷瘤小鼠体内的生物分布结果表明，^99Tc^m-MAGz—Ade在肿瘤中有较高的摄取，肿瘤与肌肉的摄取比为5．7，肿瘤与血液的摄取比为1．55。血液清除较快，有望用于非腹部肿瘤的显像。
|
| 关 键 词： | 肿瘤显像剂 肽 碱基 生物分布 |
| 文章编号： | 0253-9950(2005)02-0082-05 |
| 修稿时间： | 2005年2月25日 |
Synthesis and Biodistribution of 99Tcm-MAG2-Ade as A Tumor Imaging Agent |
| |
| ZHAO Yun-ling,ZHANG Chun-li,QI Chuan-min,YOU Gui-rong,FU Zhan-li,GUO Feng-ping,WANG Rong-fu.Synthesis and Biodistribution of 99Tcm-MAG2-Ade as A Tumor Imaging Agent[J].Journal of Nuclear and Radiochemistry,2005,27(2):82-86. |
| |
| Authors: | ZHAO Yun-ling ZHANG Chun-li QI Chuan-min YOU Gui-rong FU Zhan-li GUO Feng-ping WANG Rong-fu |
| |
| Affiliation: | ZHAO Yun-ling , ZHANG Chun-li, QI Chuan-min, YOU Gui-rong, FU Zhan-li, GUO Feng-qing, WANG Rong-fuDepartment of Chemistry, Beijing Normal University, Beijing 100875, China Department of Nuclear Medicine, Peking University, First Hospital, Beijing 100034, China |
| |
| Abstract: | A new peptide ligand containing adenine 9-N-(S-tritylmercaptoacetyl) diglycylaminoethyl] adenine (Tr-MAG2-Ade) is synthesized and characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. The complex 99Tcm-MAG2-Ade is prepared by directly labeling method. The partition coefficient and stability in vitro indicated that the complex is hydrophilic and stable over a period of 6 h at room temperature. The biodistribution of 99Tcm-MAG2-Ade in mice bearing S180 tumor shows that a tumor-specific accumulation and quick blood clearance. The uptake ratios of tumor to muscle and blood at 3 hours post injection are 5.70 and 1.55, respectively. The complex 99Tcm-MAG2-Ade appears to be a potential tumor imaging agent. |
| |
| Keywords: | tumor imaging agent peptide biological base biodistribution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《核化学与放射化学》浏览原始摘要信息 |
|
点击此处可从《核化学与放射化学》下载全文 |
|
