Wide variations of plasma triglyceride concentrations in guinea pigs |
| |
Authors: | N Mori T Murase N Yamada N Arakawa F Takaku |
| |
Affiliation: | (1) The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo, 113 Tokyo, Japan;(2) Department of Food and Nutrition, Ochanomizu University, Otsuka, 113 Tokyo, Japan |
| |
Abstract: | Guinea pigs have varying plasma triglyceride concentrations ranging from 28 to 1392 mg/dl, with relatively uniform plasma
cholesterol and phospholipid levels. To understand why the animals exhibit such wide variations of plasma triglyceride concentrations,
we have explored the triglyceride hydrolyzing system by measuring tissue lipoprotein lipase activities and plasma activator
for the enzyme. Lipoprotein lipase activities of epididymal adipose tissue of these animals were 759±117 (mean±SE) n moles
FFA·min−1·g wet tissue−1, markedly low compared with those of rats. There were no relationships between plasma triglyceride concentrations and tissue
lipase activities. Plasma activator for lipoprotein lipase was lacking in this animal. Guinea pigs with ascorbic acid deficiency
for 2 weeks also showed marked variations of plasma triglyceride concentrations, without any changes in tissue lipoprotein
lipase activities. Low adipose tissue lipoprotein lipase activities with deficient plasma activator for the enzyme suggest
that the lipoprotein lipase-mediated triglyceride degradation could be impaired in this animal, and this may account for the
marked variation of plasma triglyceride concentrations. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|