布洛芬速释固体分散体的制备及体外溶出度研究

目的:制备布洛芬速释固体分散体来提高其水溶性.方法:通过测定布洛芬在各种辅料水溶液的溶解度,及固体分散体在水中的溶出度来选择最优载体及表面活性剂.首先将药物缓慢加入到不断搅拌的无水乙醇中,完全溶解后再分别加入载体、表面活性剂和少量的蒸馏水,充分混匀后水浴加热蒸去大部分有机溶剂后放入40℃干燥箱内进行干燥,排除剩余溶剂,既得布洛芬固体分散体,测定原料药、物理混合物及固体分散体的体外溶出度.结果:当以聚乙烯吡咯烷酮k30(PVPk30)为载体,十二烷基硫酸钠(SDS)为表面活性剂时,且药物:PVPk30SDS=1 7时药物呈现了很好的水溶性.在2h内即可溶出80%.很大程度上提高了布洛芬的体外溶出度.

Research on Preparation and Dissolution Rate of Immediate-release Solid Dispersion of Ibuprofen

OBJECTIVE： Preparing the immediate-release solid dispersions of ibuprofen to enhance the watersolubility. METHODS： The optimal carrier and surfactant were chose from the solubility and dissolution test,immediate-release solid dispersions of ibuprofen have been prepared by solvent method,First added the drug into the anhydrous ethanol,after that added the carriers,surfactant and a little distilled water keep mixing until dissolved completely. Then the solid dispersion after drying on the water bath is obtained,then put it in the 40℃ dryer until the solvents were eliminated. Measuring the dissolution rate of the pure drug,physical mixure and solid dispersion. CONCLUSION： The dissolution rate improved to the 80% during 2 h,when used PVPk30 as the carriers,SDS as the surfactant and the ratio of drug： PVPk30： SDS was 1： 7： 1% in the solid dispersion system. The dissolution rate of the drug has been increased significantly.