Inclusion Complexation of Lorazepam with β — Cyclodextrin |
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Authors: | N M Sanghavi K B Choudhari R S Matharu Latha Viswanathan |
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Affiliation: |
a Pharamaceutical Section, University Department of Chemical Technology Matunga, Bombay, India |
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Abstract: | The preparation of an inclusion complex of Lorazepam, a benzodiazepine antianxiety agent with β -cyclodextrin is described. The inclusion compound was prepared by the homogeneous coprecipitation method in the molar ratio of 1:2 of the drug and β -cyclodextrin respectively. The formation of inclusion complex was evaluated by UV spectral studies, IR studies, X-ray diffractometry, and Differential Thermal Analysis. The solubility and in-vitro drug release studies indicated that the complex form of the drug significantly increase the solubility and the dissolution rate compared to the free form. Tablets prepared with Lorazepam- β -cyclodextrin complex also showed a significant increase in dissolution of the drug indicating that P-cyclodextrin plays an important role in the solubilization of the drug. |
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