| 生物催化羰基不对称还原合成手性醇的研究及应用进展 |
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| 引用本文： | 曾嵘,杨忠华,姚善泾. 生物催化羰基不对称还原合成手性醇的研究及应用进展[J]. 化工进展, 2004, 23(11): 1169-1173 |
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| 作者姓名： | 曾嵘 杨忠华 姚善泾 |
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| 作者单位： | 湖北大学化学与材料科学学院,武汉,430062;浙江大学化学工程与生物工程学系,杭州,310027 |
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| 基金项目： | 国家自然科学基金资助项目 (No 2 0 2 760 65 ) |
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| 摘 要： | 综述了国内外利用生物催化羰基的不对称还原合成手性醇的研究情况。介绍了生物催化各类潜手性羰基化合物不对称还原的原理、菌种的筛选，以及生物催化不对称还原各类羰基化合物的实例。
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| 关 键 词： | 不对称合成 不对称还原 生物催化 羰基还原 手性醇 |
| 文章编号： | 1000-6613(2004)11-1169-05 |
| 修稿时间： | 2004-05-11 |
Progress of Asymmetric Reduction of Carbonyl Compounds to Chiral Alcohol with Biocatalysis |
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| Zeng Rong ,Yang Zhonghua ,Yao Shanjing. Progress of Asymmetric Reduction of Carbonyl Compounds to Chiral Alcohol with Biocatalysis[J]. Chemical Industry and Engineering Progress, 2004, 23(11): 1169-1173 |
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| Authors: | Zeng Rong Yang Zhonghua Yao Shanjing |
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| Affiliation: | Zeng Rong 1,Yang Zhonghua 2,Yao Shanjing 2 |
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| Abstract: | The synthesis of chiral compounds has become a hot field in organic synthesis. Biotransformation is probably one of the most promising techniques in the asymmetric synthesis. The advances in asymmetric reduction of prochiral ketones to chiral alcohols with biocatalysis are reviewed. The principle of asymmetric reduction of carbonyl compounds, methodologies of screening biocatalysts and examples of practical applications are presented. |
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| Keywords: | asymmetric synthesis asymmetric reduction biocatalysis carbonyl reduction chiral alcohol |
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