| 替硝唑在水溶液中溶解度的实验测定及关联 |
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| 引用本文： | 邹莹 刘永琼 祝宏 王剑. 替硝唑在水溶液中溶解度的实验测定及关联[J]. 武汉化工学院学报, 2008, 30(1): 7-9,16 |
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| 作者姓名： | 邹莹 刘永琼 祝宏 王剑 |
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| 作者单位： | 武汉工程大学化工与制药学院,绿色化工过程省部共建教育部重点实验室,湖北省新型反应器与绿色化学工艺重点实验室,湖北武汉430074 |
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| 摘 要： | 通过自制的固-液平衡装置，采用高效液相色谱法分别测定了温度在278．15～318．15K时替硝唑在纯水、5％葡萄糖溶液和0．9％氯化钠溶液中的溶解度，并对实验数据分别采用理想溶液模型和经验方程进行了关联．对于纯水体系和0．9％氯化钠溶液体系，实验数据用理想溶液模型关联能较满意地表征实验结果．两种关联方法中，经验方程能较好地关联所测得的溶解度数据，误差较小．
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| 关 键 词： | 替硝唑 溶解度 固液平衡 高效液相色谱 理想溶液模型 经验方程 |
| 文章编号： | 1004-4736（2008）01-0007-03 |
| 收稿时间： | 2007-01-23 |
| 修稿时间： | 2007-01-23 |
Measurement and correlation of tinidazole solubilities in water systems |
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| ZOU Ying ,LIU Yong-qiong ,ZHU Hong ,WANG Jian. Measurement and correlation of tinidazole solubilities in water systems[J]. Journal of Wuhan Institute of Chemical Technology, 2008, 30(1): 7-9,16 |
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| Authors: | ZOU Ying LIU Yong-qiong ZHU Hong WANG Jian |
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| Abstract: | The solubilities of tinidazole in water,5% glucose and 10%NaCl solutions,were measured by using a solid-liquid equilibrium cell at 278.15 - 318.15 K, respectively. And the ideal solution model and a empirical equation were applied to correlate the solid-liquid equilibrium data. The solubility data obtained in water and 5% glucose solution systems are correlated with the idea solution model with satisfactory results. And the empirical equation can correlated the solubility data well with a lower error between the two correlated methods. |
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| Keywords: | tinidazole solubility solid-liquid equilibrium HPLC ideal solution model empirical equation |
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