| 乳糖酰化壳聚糖基自组装纳米载药体系的体外研究 |
| |
| 引用本文： | 陈柔,王银松,杨晓英,张彦文,李荣珊,王玉玫,王润玲.乳糖酰化壳聚糖基自组装纳米载药体系的体外研究[J].功能材料,2011,42(1):59-62. |
| |
| 作者姓名： | 陈柔 王银松 杨晓英 张彦文 李荣珊 王玉玫 王润玲 |
| |
| 作者单位： | 天津医科大学药学院; |
| |
| 基金项目： | 国家自然科学基金资助项目(30900303) |
| |
| 摘 要： | 制备乳糖酰化壳聚糖基自组装纳米微粒,用作抗肿瘤药物-甲氨喋呤(MTX)的载体,为肝靶向药物栽体系统的研究提供体外参考数椐.合成N-乳糖酰化-N-胆甾醇琥珀酰基壳聚糖(CLCS),并通过红外(IR)及核磁共振氢谱(1H NMR)对其进行结构确证.采用自组装的方法制备CLCS纳米微粒,并通过透射电镜及动态激光散射法对纳米微...
|
| 关 键 词： | 壳聚糖 自组装纳米微粒 肝靶向 药物载体 甲氨喋呤 |
The in vitro study of lactosylated chitosan based self-assembled nanoparticles as a drug carrier system |
| |
| CHEN Rou,WANG Yin-song,YANG Xiao-ying,ZHANG Yan-wen,LI Rong-shan,WANG Yu-mei,WANG Run-ling.The in vitro study of lactosylated chitosan based self-assembled nanoparticles as a drug carrier system[J].Journal of Functional Materials,2011,42(1):59-62. |
| |
| Authors: | CHEN Rou WANG Yin-song YANG Xiao-ying ZHANG Yan-wen LI Rong-shan WANG Yu-mei WANG Run-ling |
| |
| Affiliation: | CHEN Rou,WANG Yin-song,YANG Xiao-ying,ZHANG Yan-wen,LI Rong-shan,WANG Yu-mei,Wang Run-ling (School of Pharmaceutical Sciences,Tianjin Medical University,Tianjin 300070,China) |
| |
| Abstract: | This study is to prepare lactosylated chitosan-based nanoparticles used as the carrier for the anticancer drug:methotrexate(MTX) and to provide the reference data for the study of liver-targeting drug carrier systems.Firstly,N-lactosyl-chitosan conjugate(CLCS) was synthesized and characterized by FT-IR and 1H NMR.Secondly,CLCS nanoparticles were prepared by the self-assemble method,and their size and morphological characteristics were analyzed by dynamic laser light scattering and transmission electron micr... |
| |
| Keywords: | chitosan nanoparticle liver-targeting drug carrier methotrexate |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
