Generic brain activation mapping in functional magnetic resonance imaging: a nonparametric approach |
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Authors: | MJ Brammer ET Bullmore A Simmons SC Williams PM Grasby RJ Howard PW Woodruff S Rabe-Hesketh |
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Affiliation: | Department of Biostatistics, Institute of Psychiatry, London. m.brammer@iop.bpmf.ac.uk |
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Abstract: | We report a novel method to identify brain regions generically activated by periodic experimental design in functional magnetic resonance imaging data. This involves: 1) registering each of N individual functional magnetic resonance imaging datasets in a standard space; 2) computing the median standardised power of response to the experimental design; 3) testing median standardised power at each voxel against its nonparametrically ascertained distribution under the null hypothesis of no experimental effect; and 4) constructing a generic brain activation map. The method is validated by analysis of 6 null images, acquired under conditions when the null hypothesis was known to be true; 8 images acquired during periodic auditory-verbal stimulation; and 6 images acquired during periodic performance of a covert verbal fluency task. |
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