Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase |
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| Authors: | Borràs J Casanova J Cristea T Gheorghe A Scozzafava A Supuran C T Tudor V |
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| Affiliation: | University of Valencia Faculty of Pharmacy Department of Inorganic Chemistry, Vincent Andres Estelles s/n Burjassot (Valencia) E-46100 Spain. |
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| Abstract: | Ternary Ni(II) complexes of hydrazine and eight heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties, were prepared and characterized by elemental analysis, spectroscopic, magnetic, thermogravimetric, and conductimetric measurements. The complexes behave as strong inhibitors for two isozymes (I and II) of carbonic anhydrase. |
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