In vivo correlation between semi‐quantitative hemodynamic parameters and Ktrans derived from DCE‐MRI of brain tumors |
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| Authors: | Chen Chih‐Feng Hsu Ling‐Wei Lui Chun‐Chung Lee Chen‐Chang Weng Hsu‐Huei Tsai Yuan‐Hsiung Liu Ho‐Ling |
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| Affiliation: | 1. Department of Diagnostic Radiology, Chang Gung Memorial Hospital, ChiaYi Branch, College of Medicine and School of Medical Technology, ChiaYi, Taiwan;2. Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan;3. Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan |
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| Abstract: | Dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow‐up. Without complicated calculation, a semiquantitative parameter – modified initial area under the curve (mIAUCc) – was proposed for better correlation with volume transfer constant (Ktrans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUCc and Ktrans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3‐Tesla clinical MR scanner. The results showed that mIAUCc was highly correlated with Ktrans with the correlation coefficient of 0.913. Although the ideals of Ktrans and mIAUCc are different, mIAUCc does the trick for brain tumors evaluations in DCE‐MRI. It reveals that mIAUCc could be an alternative for physiological condition evaluation in DCE‐MRI. © 2012 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 22, 132–136, 2012 |
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| Keywords: | magnetic resonance imaging dynamic contrast enhanced initial area under the curve volume transfer constant |
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