| 3-甲基-2-氧代丁酸的合成研究进展 |
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| 引用本文： | 陈爱军,何国新,刘赛.3-甲基-2-氧代丁酸的合成研究进展[J].广州化工,2010,38(2):26-27. |
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| 作者姓名： | 陈爱军 何国新 刘赛 |
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| 作者单位： | 南京生命能科技开发有限公司,江苏南京,210016 |
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| 摘 要： | 3-甲基-2-氧代丁酸是一类双官能团化合物,性质活泼而特殊,是药物合成及生物转化的重要中间体,其钙盐多年来一直被应用于泌尿系统疾病的治疗。综述了3-甲基-2-氧代丁酸的主要合成方法,并结合工艺特点,对适合工业化生产使用的合成方法进行对比分析。
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| 关 键 词： | 3-甲基-2-氧代丁酸 合成 工业化生产 |
Research Progress on the Synthesis of 3-methyl-2-oxo-butanoic Acid |
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| CHEN Ai-jun,HE Guo-xin,LIU Sai.Research Progress on the Synthesis of 3-methyl-2-oxo-butanoic Acid[J].GuangZhou Chemical Industry and Technology,2010,38(2):26-27. |
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| Authors: | CHEN Ai-jun HE Guo-xin LIU Sai |
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| Affiliation: | Nanjing Lifenergy R & D Co.;Ltd.;Jiangsu Nanjing 210016;China |
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| Abstract: | 3-Methyl-2-oxo-butanoic acid was a kind of bifunctional compound with special and active nature.It was an important intermediate for drug synthesis and biological transformation.And its calcium salt,as an effective drug,was used to treat urinary disease for many years.The main synthesis methods of 3-methyl-2-oxo-butanoic acid were reviewed.Combining technological features,a detailed comparative analysis of preparation methods,suitable for industrial production,was supplied. |
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| Keywords: | 3-methyl-2-oxo-butanoic acid synthesis industrial production |
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