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Stimulatory effects of tannins and cholic acid on tryptic hydrolysis of proteins: Ecological implications
Authors:Simon Mole  Peter G Waterman
Affiliation:(1) Phytochemistry Research Laboratories Department of Pharmacy (Pharmaceutical Chemistry), University of Strathclyde, G1 1XW Glasgow, Scotland
Abstract:The biochemical basis for considering tannins as digestion inhibitors has been reexamined. Both stimulatory and inhibitory effects of tannins on tryptic hydrolysis are reported. We show how stimulation may result from tannin-induced structural changes in the substrate protein, effectively denaturing it. The surfactant and bile constituent cholic acid also produced similar stimulatory effects. These results have considerable implications for normal digestive physiology as well as for the impact of tannins on argicultural and natural herbivore populations.
Keywords:Tannins  digestion  herbivory  digestibility-reducing substances  gut surfactants  bile acids  tannin-protein interactions
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