Development of peristaltic antithrombogenic micropumps for in vitro and ex vivo blood transportation tests |
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Authors: | Yi-Chu Hsu Sung-Ju Lin Ching-Cheng Hou |
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Affiliation: | (1) Department of Mechanical Engineering, Southern Taiwan University of Technology, 1 Nan-Tai Street, Yung Kang City 710, Tainan County, Taiwan;(2) Department of Intensive Care Medicine, Chi Mei Hospital, Liouying Campus, 901, Chung Hwa Rood, Yung Kang City 710, Tainan County, Taiwan |
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Abstract: | This study involves the design, fabrication and characterization of a biocompatible silicon micropump. Three experiments were
conducted to study the performance of this pump in clinical environments. They were a blood compatibility test, and in vitro
and ex vivo studies. Whole blood is an intrinsically complex material and difficult to manipulate using a microsystem device.
In the blood compatibility experiments, two materials N-(triethosilylpropyl)-O-polyethylene oxide urethane (PEOU) and polyethylene glycol (PEG) were employed to form a self-assembled monolayer (SAM) on
a chip surface. According to the platelet remaining test and a 30-min blood transportation test, PEOU protected the micropump
from thrombus. In the second experiment, the micropump handled several liquids, including DI water and whole blood. When the
pump was operated at a voltage of 140 Vpp, the flow rates of the DI water and whole blood were 121.6 μl/min at 500 Hz and 50.2 μl/min at 450 Hz, respectively. The
maximum back pressure of the water and the blood in the micropump were 3.2 and 1.8 kPa, respectively. Finally, the micropump
injected phosphated buffered saline (PBS) and whole blood into the veins of rats. The pump was characterized ex vivo and discussed.
The third experiment reveals that the micropump fulfilled the dosing condition for clinical medicine and did not affect the
physiological function of the rats. This pump is highly promising for biomedical applications, such as in drug delivery for
patients, or in clinical care. Moreover, the pump has potentials to control precisely medication to improve conventional clinical
treatments. |
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