苯并噻唑类化合物对高脂模型小鼠抗氧化能力的影响

研究苯并噻唑类化合物TJ-1（2-间苯胺基苯并噻唑）、TJ-2（2-间苯胺基苯并噻唑-3，4，5-三甲氧基苯甲酰胺）、TJ-3（2-间苯胺基苯并噻唑-1H-吡唑-3-甲酰胺）对高脂模型小鼠抗氧化能力的影响．50只8周龄健康雄性C57BL／6J小鼠适应性饲养1周后，根据体质量随机分为高脂组、白藜芦醇对照组、TJ．1组、TJ-2组和TJ-3组．高脂组喂饲相应高脂饲料，白藜芦醇对照组和各干预组小鼠喂饲高脂饲料并分别添加0．1％的白藜芦醇、TJ-1、TJ-2、TJ-3进行干预，干预12周后测定小鼠血清、肝脏和脑的超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH．Px）、过氧化氢酶（CAT）和丙二醛（MDA）的水平．与高脂组相比，TJ-1、TJ-2、TJ-3、白藜芦醇各组小鼠血清、肝脏和脑的SOD、GSH．Px、CAT水平均高于高脂模型组，MDA水平低于高脂组．结果表明：苯并噻唑类化合物能改善高脂模型小鼠的抗氧化能力．

Effect of Benzothiazole Derivatives on the Antioxidating Activities of High-fat Fed Mice

The effect of benzothiazole derivatives TJ-1 （3- （benzod]thiazol-2-yl） benzenamine）, TJ-2 （N- （3- （benzod] thiazol- 2-yl） phenyl）-3,4,5-trimethoxybenzamide）, and TJ-3 （N- （3- （benzod]thiazol-2-yl） phenyl） -1 H-pyrazole-3-carboxamide） on the antioxidating activities of mice with high fat diet was studied. Fifty 8-week-old male C57BL/6 J mice were quaran- tined for 1 week. They were then randomly assigned to the following five groups according to body weight：high fat diet group,resveratrol control group,TJ-1 group,TJ-2 group and TJ-3 group. The levels of superoxide dismutase（SOD）, glutathione peroxidase（GSH-Px）,catalase（CAT）and malondialdehyde（MDA）were measured after the treatment which lasted for 12 weeks. Compared with the high fat diet group, the SOD, GSH-Px and CAT levels in the serum, liver and brain of the other 4 groups were higher, and the MDA levels were lower. Benzothiazole derivatives can improve the antioxidating activities of high fat mice.