Metabolic peculiarity of 134Cs and its radioimmunotoxicological effect on central and peripheral immune cells

A fitted equation with least square method to describe the retention of ^134Cs in whole body is obtained by a whole body counter.That is R(t)=18.04exp(-9.3175t) 45.13exp(-0.0423t),where R(t) is in %,and t in d.The equationn consists of two half-life components,the fast component is T1/2=0.07d,and the slow is T1/2=16.14d,Study on the localization of ^134Cs at cellular level was carried out by freezing microautoradiography.The results indicate of ^134Cs at cellular level was carried out by freezing microautoradiography.The results indicate that ^134Cs was chiefly in ionizing form accumulated in red as well as white blood cells.In bone marrow cells ^134Cs predominantly deposited in young cells and less in mature cells.Distribution of ^134Cs penetrated quickly into the tissue cells.The observation of investigating radioimmunotoxicological effect induced by ^134Cs shows that the inhibition of thymocytes is higher than bone marrow cells,the spleen T lynmphocytes are more sensitive to ^134Cs than B lymphocytes and lymphocytes of peripheral immune cells are more sensitive to radiation than central immune cells.