Production of fine lactose particles from organic solvent in laboratory and commercial-scale spray dryers |
| |
Authors: | I C Kemp T Hartwig P Hamilton R Wadley A Bisten |
| |
Affiliation: | 1. Glaxo SmithKline, R&2. D, Stevenage, UK |
| |
Abstract: | A laboratory spray dryer and a commercial dryer with a production rate 50 times greater, both using two-fluid nozzles, were used to dry the same formulation from organic solvent. Both dryers generated particles of similar size, with tight particle size distributions (span <2), which varied with atomization gas flow rate, liquid flow rate, and solids concentration. Small-scale results with an external mixing nozzle were fitted to a correlation based on literature recommendations. This also fitted well for the commercial dryer with external mixing, and an internal mixing nozzle gave a tighter size distribution. Hence, successful verification at scale has been achieved. |
| |
Keywords: | Atomization concentration inhalable particle size scale-up spray dryer two-fluid nozzle |
|
|