Spray drying with a two-fluid nozzle to produce fine particles: Atomization,scale-up,and modeling |
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Authors: | I. C. Kemp T. Hartwig R. Herdman P. Hamilton A. Bisten S. Bermingham |
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Affiliation: | 1. GlaxoSmithKline plc, R&2. D, Medicines Research Centre, Stevenage, UK;3. Process Systems Enterprise, London, UK |
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Abstract: | This article presents experimental and modeling work to complete previously reported work on spray drying. Back-calculated droplet sizes have been verified by measurements with a laser imaging rig. Flow patterns in a cylindrical spray chamber have been simulated by computational fluid dynamics and demonstrated that droplet residence times are much shorter than expected. A droplet tracking population balance model has been implemented in gSOLIDS and shows how drying times vary with droplet diameter. Particle collection by cyclone and bag filter have also been compared experimentally. |
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Keywords: | Atomization CFD cyclone droplet size measurement particle collection residence time |
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