A Novel Dinucleating Ligand-Containing Hexabenzimidazoles and Its Dinuclear Zinc Complex Bridged by a Carboxylate Group for the Hydrolysis of 2-Hydroxypropyl-p-nitrophenyl phosphate |
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Authors: | Mohamed M Ibrahim |
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Affiliation: | (1) Chemistry Department, Faculty of Education, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt;(2) Chemistry Deprtment, Faculty of Science, Taif University, 888 Alhawiya, Taif, Kingdom of Saudi Arabia |
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Abstract: | A dinuclear zinc(II) complex with the ligand bis{tris2-(1-methylbenzimidazole-2-yl)ethyl]-methylamine}nitrilotriacetic acid
sodium salt, L, was synthesized and characterized. Complex formation of L with Zn2+ in aqueous acetone was studied by Zn2+ titration using 1H NMR and UV–vis spectroscopies. Analysis of the titration data indicates the formation of a dizinc complex. The νas(COO−) and νs(COO−) stretches were observed at 1572 and 1450 cm−1, respectively. The low separation of the stretches, Δexp = 115 cm−1, is an indication of chelating coordination of the carboxylate group between the two zinc(II) ions. The catalytic activity
of LZn2]3+
1, as a model for phosphatase that catalyze chemical transformation of phosphate ester, in the hydrolysis of the RNA model, 2-hydroxypropyl p-nitrophenyl phosphate, was examined in aqueous acetone buffer solution, pH 7.0–9.5. The mechanism of the catalytic hydrolysis
suggests that the rate of acceleration is due to what is called double Lewis acid activation. |
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