| 刺五加皂甙提取物对小鼠睡眠作用观察 |
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| 引用本文： | 李文仙,周一萍,林玲,黄建,孙静,霍军生. 刺五加皂甙提取物对小鼠睡眠作用观察[J]. 中国食品添加剂, 2010, 0(2) |
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| 作者姓名： | 李文仙 周一萍 林玲 黄建 孙静 霍军生 |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100050 |
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| 摘 要： | 研究目的在于观察刺五加皂甙对小鼠睡眠的影响。采用乙醇回流法提取刺五加皂甙,提取物总皂甙含量2.5%。分别以刺五加皂甙提取物低、中、高级量(2.5、5、10mg/kg.bw)连续灌胃小鼠30d,观察不同剂量刺五加皂甙组与对照组小鼠在注射戊巴比妥后30min内睡眠发生率、睡眠潜伏期和睡眠延长时间。中、高剂量组的戊巴比妥钠诱导小鼠睡眠时间比对照组显著延长(P0.05或P0.01),且戊巴比妥钠诱导的小鼠睡眠潜伏期显著低于对照组(P0.05),高剂量刺五加皂甙对阈下剂量巴比妥钠诱导小鼠睡眠发生率有显著影响(P0.05)。实验中未发现刺五加皂甙对小鼠有直接睡眠作用。结果显示刺五加皂甙提取物具有促进小鼠改善睡眠的作用。
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| 关 键 词： | 刺五加 皂甙 睡眠 |
Effect of extract of acanthopanax senticosus saponins on sleep performance of mice |
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| LI Wen-xian,ZHOU Yi-ping,LIN Lin,HUANG Jian,SUN Jing,HUO Jun-sheng. Effect of extract of acanthopanax senticosus saponins on sleep performance of mice[J]. China Food Additives, 2010, 0(2) |
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| Authors: | LI Wen-xian ZHOU Yi-ping LIN Lin HUANG Jian SUN Jing HUO Jun-sheng |
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| Affiliation: | LI Wen-xian,ZHOU Yi-ping,LIN Lin,HUANG Jian,SUN Jing,HUO Jun-sheng(Chinese Center for Disease Control , Prevention,Beijing 100050) |
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| Abstract: | The study was designed to observe effect of extract of acanthopanax senticosus saponins(ASS)on sleep performance of mice.ASS extract was prepared by ethanol solution circumfluence method and ASS content of the extract was 2.5%.Mice were divided into four groups as control and dosages of high,meddle and low(2.5,5,10mg/kg.bw)of the extract.Mice were oral administrated for 30 days.Sleep rate,latent period and sleep time after pentobarbital injection were observed.Sleep time of high and meddle dosage groups sho... |
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| Keywords: | acanthopanax senticosus saponins sleep performance |
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